{"id":27370,"date":"2026-04-16T11:12:33","date_gmt":"2026-04-16T11:12:33","guid":{"rendered":"https:\/\/algicel.pt\/?p=27370"},"modified":"2026-04-16T11:12:35","modified_gmt":"2026-04-16T11:12:35","slug":"what-is-low-grade-inflammation-and-why-cant-it-be-felt","status":"publish","type":"post","link":"https:\/\/algicel.pt\/en\/what-is-low-grade-inflammation-and-why-cant-it-be-felt\/","title":{"rendered":"Low-grade inflammation: what it is and why you can't feel it"},"content":{"rendered":"<!-- \n  Sa\u00fade & Biologia Celular \u2014 Artigo A02\n  Inflama\u00e7\u00e3o de baixo grau: o que \u00e9 e porque n\u00e3o se sente\n  Compat\u00edvel com WordPress 6.x + DIVI (uma coluna, sem hero)\n  Fonte: Google Fonts via @import\n-->\n\n<style>\n  @import 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padding-right: 22px !important;\n      max-width: 100% !important;\n    }\n\n    .sbc-article .sbc-title,\n    .et_pb_text .sbc-article .sbc-title,\n    .entry-content .sbc-article .sbc-title,\n    .post-content .sbc-article .sbc-title {\n      font-size: 15px !important;\n    }\n\n    .sbc-article h2,\n    .et_pb_text .sbc-article h2,\n    .entry-content .sbc-article h2,\n    .post-content .sbc-article h2 {\n      font-size: 13px !important;\n    }\n\n    .sbc-article h2 .section-num,\n    .et_pb_text .sbc-article h2 .section-num,\n    .entry-content .sbc-article h2 .section-num,\n    .post-content .sbc-article h2 .section-num {\n      font-size: 26px !important;\n      min-width: 40px !important;\n    }\n  }\n\n  @media (max-width: 560px) {\n    .sbc-compare {\n      grid-template-columns: 1fr;\n    }\n\n    .sbc-article {\n      font-size: 16px;\n      padding-left: 18px !important;\n      padding-right: 18px !important;\n    }\n\n    .sbc-article .sbc-title,\n    .et_pb_text .sbc-article .sbc-title,\n    .entry-content .sbc-article .sbc-title,\n    .post-content .sbc-article .sbc-title {\n      font-size: 14px !important;\n      line-height: 1.22 !important;\n    }\n\n    .sbc-article h2,\n    .et_pb_text .sbc-article h2,\n    .entry-content .sbc-article h2,\n    .post-content .sbc-article h2 {\n      font-size: 12.5px !important;\n      gap: 10px !important;\n    }\n\n    .sbc-article h2 .section-num,\n    .et_pb_text .sbc-article h2 .section-num,\n    .entry-content .sbc-article h2 .section-num,\n    .post-content .sbc-article h2 .section-num {\n      font-size: 24px !important;\n      min-width: 36px !important;\n    }\n  }\n<\/style>\n\n<article class=\"sbc-article\">\n\n  <!-- Kicker -->\n  <span class=\"sbc-kicker\">Health &amp; Cell Biology<\/span>\n\n  <!-- T\u00edtulo -->\n  <h1 class=\"sbc-title\">Low-grade inflammation: <em>what it is and why you can't feel it<\/em><\/h1>\n\n  <!-- Lead -->\n  <p class=\"sbc-lead\">Not all processes in the body are obvious. Some manifest themselves clearly: pain, fever, swelling. Others do not, and it is precisely in this silence that low-grade inflammation persists.<\/p>\n\n  <hr class=\"sbc-divider\">\n\n  <!-- Sec\u00e7\u00e3o 1 -->\n  <h2><span class=\"section-num\">01<\/span> Conceptual introduction<\/h2>\n\n  <p>Low-grade inflammation belongs to the second group. It doesn't hurt, it doesn't bother you directly. And most of the time, it's not noticed.<\/p>\n\n  <p>But that doesn't mean it doesn't exist. It just means that the body is dealing with a process that is continuous, silent and often prolonged over time.<\/p>\n\n  <!-- Sec\u00e7\u00e3o 2 -->\n  <h2><span class=\"section-num\">02<\/span> What is low-grade inflammation<\/h2>\n\n  <p>Inflammation is a normal mechanism in the body. It is the immune system's response to infections, injuries and internal or external aggressions.<\/p>\n\n  <p>When it's acute, it's easy to recognise. Low-grade inflammation is different:<\/p>\n\n  <div class=\"sbc-compare\">\n    <div class=\"sbc-compare-box acute\">\n      <span class=\"compare-label\">Acute inflammation<\/span>\n      <ul>\n        <li>Redness<\/li>\n        <li>Heat<\/li>\n        <li>Pain<\/li>\n        <li>Swelling<\/li>\n        <li>Localised and temporary<\/li>\n      <\/ul>\n    <\/div>\n    <div class=\"sbc-compare-box chronic\">\n      <span class=\"compare-label\">Low-grade inflammation<\/span>\n      <ul>\n        <li>Less intense<\/li>\n        <li>More diffuse<\/li>\n        <li>Persistent over time<\/li>\n        <li>No obvious symptoms<\/li>\n        <li>Light but continuous activation<\/li>\n      <\/ul>\n    <\/div>\n  <\/div>\n\n  <p>Instead of a strong, localised response, there is a mild but continuous activation of the immune system. From a biological point of view, this state is often associated with slightly elevated levels of inflammatory mediators:<\/p>\n\n  <div class=\"sbc-infobox\">\n    <span class=\"infobox-label\">Frequently associated biological markers<\/span>\n    <ul>\n      <li>Pro-inflammatory cytokines (e.g. IL-6, TNF-\u03b1)<\/li>\n      <li>C-reactive protein (CRP) at low but persistent levels<\/li>\n    <\/ul>\n  <\/div>\n\n  <p>It's not a disease. It's a <strong>altered physiological state<\/strong>, which can last for years.<\/p>\n\n  <!-- Sec\u00e7\u00e3o 3 -->\n  <h2><span class=\"section-num\">03<\/span> Why this state arises<\/h2>\n\n  <p>Low-grade inflammation doesn't usually have a single cause. It is usually the result of a set of accumulated factors:<\/p>\n\n  <ul>\n    <li>Excess calories over time<\/li>\n    <li>Poor food quality<\/li>\n    <li>Sedentary lifestyle<\/li>\n    <li>Sleep deprivation<\/li>\n    <li>Persistent psychological stress<\/li>\n    <li>Overstimulation and poor recovery<\/li>\n    <li>Metabolic changes (such as insulin resistance)<\/li>\n  <\/ul>\n\n  <div class=\"sbc-pullquote\">\n    It's not an isolated event, it's a biological context. The body adapts to this context, and this adaptation can include constant but discreet inflammatory activation.\n  <\/div>\n\n  <!-- Sec\u00e7\u00e3o 4 -->\n  <h2><span class=\"section-num\">04<\/span> Because you don't feel<\/h2>\n\n  <p>This is the central question. If there is inflammation, why doesn't it hurt?<\/p>\n\n  <p>The answer lies in the intensity and the way the body signals. Acute inflammation activates mechanisms that produce clear symptoms. Low-grade inflammation does not. It's a process:<\/p>\n\n  <ul>\n    <li>Systemic (distributed throughout the body)<\/li>\n    <li>Low intensity<\/li>\n    <li>No strong activation of pain systems<\/li>\n  <\/ul>\n\n  <p>What's more, the body has a great capacity for compensation. While this compensation is working, there are no obvious signs, no clear perception.<\/p>\n\n  <div class=\"sbc-highlight\">\n    The brain tends to value acute signals, not subtle chronic states. In other words, what doesn't change quickly or cause direct discomfort tends to go unnoticed.\n  <\/div>\n\n  <!-- Sec\u00e7\u00e3o 5 -->\n  <h2><span class=\"section-num\">05<\/span> What this means in practice<\/h2>\n\n  <p>The absence of sensation can lead to misinterpretation:<\/p>\n\n  <div class=\"sbc-pullquote\">\u00abIf I don't feel anything, everything's fine.\u00bb<\/div>\n\n  <p>But biologically, this isn't necessarily true. A low-grade inflammatory state can coexist with a sense of normality, an apparently stable routine and the absence of clear symptoms.<\/p>\n\n  <p>And over time, it can be associated with progressive changes such as:<\/p>\n\n  <ul>\n    <li>Lower metabolic efficiency<\/li>\n    <li>Slower recovery<\/li>\n    <li>Greater sensitivity to physiological stress<\/li>\n    <li>Changes in energy regulation<\/li>\n  <\/ul>\n\n  <p>None of this comes abruptly. It's gradual, which is why it's often only recognised late.<\/p>\n\n  <!-- Sec\u00e7\u00e3o 6 -->\n  <h2><span class=\"section-num\">06<\/span> Relationship with other biological processes<\/h2>\n\n  <p>Low-grade inflammation rarely exists in isolation. It is often linked to other processes, such as<\/p>\n\n  <ul>\n    <li>Metabolic changes<\/li>\n    <li>Oxidative stress<\/li>\n    <li>Mitochondrial dysfunction<\/li>\n  <\/ul>\n\n  <p>These processes can reinforce each other. But the relevant point here is not the complexity of the mechanism. It's realising that the body works as an integrated system and that small persistent changes can accumulate.<\/p>\n\n  <p>And this accumulation doesn't need to be felt in order to exist.<\/p>\n\n  <!-- S\u00edntese -->\n  <h2><span class=\"section-num\">07<\/span> Summary<\/h2>\n\n  <div class=\"sbc-synthesis\">\n    <span class=\"synthesis-label\">Key points<\/span>\n    <ul>\n      <li>Inflammation is a normal mechanism of the body<\/li>\n      <li>It can be acute (visible) or low-grade (invisible)<\/li>\n      <li>Low-grade inflammation is persistent and of low intensity<\/li>\n      <li>No clear symptoms in most cases<\/li>\n      <li>It arises from prolonged contexts, not isolated events<\/li>\n      <li>The absence of sensation does not mean the absence of process<\/li>\n    <\/ul>\n  <\/div>\n\n<!-- CTA -->\n<div class=\"sbc-cta\">\n  <span class=\"cta-label\">To go deeper<\/span>\n  <p>If you want to delve deeper into this topic and understand how different everyday factors influence these processes over time, you can consult the guide:<\/p>\n  <strong>\n    <a href=\"https:\/\/8e94e84c.sibforms.com\/serve\/MUIFAMz_4t2bHwlcaMOWbx101E5K5cFIQLm8S6UuqhIUfTWeX5Pb0PkkvVM5-3jx9mOmc4raksRnX3P2A8SHV_WbnTWOy3EWKYGjXRk1G-3SQp8Ugs9oGpZZ4It64_rtN_EP5DbimccnKz6oVi4bINazh4w88wlDcOZ64H4c9lxikMTkxw0KAOk-7oF_sVXxavkBtSFEc_uBVGIE9g==\" target=\"_blank\">\n      \u00abHow to protect cells in the long term\u00bb\n    <\/a>\n  <\/strong>\n<\/div>\n\n  <!-- Autor -->\n  <div class=\"sbc-author\">\n    <div class=\"sbc-author-avatar\">E<\/div>\n    <div class=\"sbc-author-info\">\n      <p class=\"author-name\">Emanuel Xavier, PhD in Biology<\/p>\n      <p class=\"author-role\">Scientific collaborator at Algicel \/ Azora<\/p>\n    <\/div>\n  <\/div>\n\n  <!-- Refer\u00eancias -->\n  <div class=\"sbc-references\">\n    <p class=\"ref-heading\">Scientific references<\/p>\n    <ol>\n      <li>\n        Hotamisligil GS. Inflammation and metabolic disorders. <em>Nature.<\/em> 2006;444(7121):860\u2013867.<br>\n        <a class=\"ref-doi\" href=\"https:\/\/doi.org\/10.1038\/nature05485\" target=\"_blank\" rel=\"noopener\">doi:10.1038\/nature05485<\/a>\n      <\/li>\n      <li>\n        Calder PC, et al. Low-grade inflammation and metabolic health. <em>British Journal of Nutrition.<\/em> 2011;106(S3):S5-S7.<br>\n        <a class=\"ref-doi\" href=\"https:\/\/doi.org\/10.1017\/S0007114511005451\" target=\"_blank\" rel=\"noopener\">doi:10.1017\/S0007114511005451<\/a>\n      <\/li>\n      <li>\n        Libby P. Inflammation in atherosclerosis. <em>Nature.<\/em> 2002;420(6917):868\u2013874.<br>\n        <a class=\"ref-doi\" href=\"https:\/\/doi.org\/10.1038\/nature01323\" target=\"_blank\" rel=\"noopener\">doi:10.1038\/nature01323<\/a>\n      <\/li>\n      <li>\n        Furman D, et al. Chronic inflammation in the etiology of disease across the life span. <em>Nature Medicine.<\/em> 2019;25(12):1822\u20131832.<br>\n        <a class=\"ref-doi\" href=\"https:\/\/doi.org\/10.1038\/s41591-019-0675-0\" target=\"_blank\" rel=\"noopener\">doi:10.1038\/s41591-019-0675-0<\/a>\n      <\/li>\n    <\/ol>\n  <\/div>\n\n<\/article>","protected":false},"excerpt":{"rendered":"<p>Sa\u00fade &amp; Biologia Celular Inflama\u00e7\u00e3o de baixo grau: o que \u00e9 e porque n\u00e3o se sente Nem todos os processos no corpo s\u00e3o evidentes. Alguns manifestam-se de forma clara: dor, febre, incha\u00e7o. Outros n\u00e3o e \u00e9 precisamente nesse sil\u00eancio que a inflama\u00e7\u00e3o de baixo grau persiste. 01 Introdu\u00e7\u00e3o conceptual A inflama\u00e7\u00e3o de baixo grau pertence [&hellip;]<\/p>","protected":false},"author":2866,"featured_media":27278,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[79],"tags":[],"class_list":["post-27370","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-stress-oxidativo-e-base-biologica"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v26.7 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Inflama\u00e7\u00e3o de baixo grau: o que \u00e9 e porque n\u00e3o se sente - Algicel<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/algicel.pt\/en\/what-is-low-grade-inflammation-and-why-cant-it-be-felt\/\" \/>\n<meta property=\"og:locale\" content=\"en_GB\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Inflama\u00e7\u00e3o de baixo grau: o que \u00e9 e porque n\u00e3o se sente - Algicel\" \/>\n<meta property=\"og:description\" content=\"Sa\u00fade &amp; Biologia Celular Inflama\u00e7\u00e3o de baixo grau: o que \u00e9 e porque n\u00e3o se sente Nem todos os processos no corpo s\u00e3o evidentes. Alguns manifestam-se de forma clara: dor, febre, incha\u00e7o. 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